BICORE has 5 modules encompassing 18 projects

Modules I (Population-based), II (Biological mechanisms) and III (Intervention) represent the core investigative nature of BICORE. Module IV (Converging) will investigate models dealing with the complexity of the data and module V (Management) is a PMBOK project management analysis.

MOdule I: population-base cognitive reserve parameters

In this module we intent to investigate the brain structure, function and connectivity using functional Magnetic Resonance Imaging (fMRI) in conjunction with neuropsychological and genetic data from 900+ subjects - mostly derived from the SABE project. Projects and Principal Investigators:

1. Neuropsychological Predictors of Cognitive Reserve in Elderly - Edson Amaro Jr, Sonia Brucki, Shirley Silva Lacerda
2. Cerebral Predictors of Cognitive Brain Reserve in Elderly  - David Bennett, José Farfel, Wilson Jacob, Helmut Heinsen
3. Genetic Wide Association Study in octogenarians - Mayana Zatz, Michel Naslavski and Maria Lucia Lebrão
4. Healthy cerebrovascular reactivity, lifestyle and cognitive impairment - Felipe Brunetto Tancredi, Fabio Gazelato
5. Status epilepticus risk analysis in elderly patients ( ARSEPI ) - Birajara Machado, Luiz Otavio Caboclo

Module II: Biological Determinants of cognitive reserve

In this module we will investigate the biological basis and mechanisms involved in Brain Cognitive Reserve using pre-clinical and experimental models of disease and normal aging processes.Projects and Principal Investigators:

1. Biomarkers Study of Brain Aging by Analyses of Metabolomics , lipidomics and Genomics ( EBECAMLG ) - Claudia Cristina F. Barros
2. Analysis of the Tyrosine hydroxylase - expression and dopamine levels in Natural Aging Process and Pathological using model D. Parkinson - Lionel Farnel Gamarra
3. Genetic and behavioral traits of neural reserve induced by early physical activity in rats - Sergio Gomes da Silva
4. Parkinsonian syndrome: study of the molecular mechanisms involved in the neurodegenerative process - Patricia Maria C. Aguiar

Module III: Testing cognitive reserve concepts

In this module we will investigate the concept of Cognitive Reserve using intervention study designs. Three of the projects in this module will investigate potential conditions contributing to deplenish cognitive reserve. The remaining five projects will investigate potential activities to boost individual cognitive reserve during natural aging process.Projects and Principal Investigators:

- Negative effects:

1. Brain Reserve and subclinical lesions in Ischemic Cerebral Vascular Accident ( RELEVASC ) - Adriana Bastos Conforto
2. Assessment of cognitive reserve in patients with brain metastases undergoing radiotherapy of the brain - Eduardo Weltman
3. Magnetic resonance imaging and PET associated with the analysis of neurological variables, neuropsychology and genotyping using intelligent classifiers (machine learning) - Ivan Hideyo Okamoto and Maryana Allegro
4. Chemotherapy effects in Cognitive Reserve - Edson Amaro Jr, Shirley Lacerda, Elisa Harumi, Lorenzo Cohen

- Positive effects:

5. Language learning effects in cognitive reserve - Edson Amaro Jr, Kelly Costok, Letícia Mansur, Ricardo Nitrini
6. Tai Chi as a practice to improve balance and attention in the elderly: a longitudinal study of movement , cognition and brain structure and functions - Elisa Harumi Kozasa
7. Cognitive Training Analysis based on computer games (Gamming): effects in Cognitive Reserve - Leticia Guimarães Lyle, Thais Guimarães and Livia Valentim
8. Music, Ageing and Cognitive Reserve - Patricia Vanzella and João Ricardo Sato

Module IV: A biologically plausible index from converging cognitive reserve biomarkeRS

In this module we will investigate different techniques to converge multi-parametric data from all previous modules. The aim is to: a) test current proposed indexes and b) create a unique Brain Cognitive Reserve using data from modules I (population-based) and III (intervention studie). Projects and Principal Investigators:

1. Generation of a multi-parameter indicator of Brain Reserve - João R. Sato

Module V: Analyzing Project Management technologies

In this module we will investigate different techniques to control/reprogram project management techniques. The aim is to: a) test current PMBOK techniques and b) create and test an index based on return over investiment. Projects and Principal Investigators:

1. Project Management Technologies applied to the  BICORE Project - Aline Rodrigues Pacifico